Phylogeny-based tumor subclone identification using a Bayesian feature allocation model
نویسندگان
چکیده
منابع مشابه
Phylogeny-based tumor subclone identification using a Bayesian feature allocation model
Tumor cells acquire different genetic alterations during the course of evolution in cancer patients. As a result of competition and selection, only a few subgroups of cells with distinct genotypes survive. These subgroups of cells are often referred to as subclones. In recent years, many statistical and computational methods have been developed to identify tumor subclones, leading to biological...
متن کاملA Bayesian feature allocation model for tumor heterogeneity
We develop a feature allocation model for inference on genetic tumor variation using next-generation sequencing data. Specifically, we record single nucleotide variants (SNVs) based on short reads mapped to human reference genome and characterize tumor heterogeneity by latent haplotypes defined as a scaffold of SNVs on the same homologous genome. For multiple samples from a single tumor, assumi...
متن کاملBayesian logistic regression using a perfect phylogeny.
Haplotype data capture the genetic variation among individuals in a population and among populations. An understanding of this variation and the ancestral history of haplotypes is important in genetic association studies of complex disease. We introduce a method for detecting associations between disease and haplotypes in a candidate gene region or candidate block with little or no recombinatio...
متن کاملChemical Identification using Bayesian Model Selection
Remote detection and identification of chemicals in a scene is a challenging problem. We introduce an approach that uses some of the image’s pixels to establish the background characteristics while other pixels represent the target for which we seek to identify all chemical species present. This leads to a generalized least squares problem in which we focus on “subset selection” to identify the...
متن کاملPredicting waste generation using Bayesian model averaging
A prognosis model has been developed for solid waste generation from households in Hoi An City, a famous tourist city in Viet Nam. Waste sampling, followed by a questionnaire survey, was carried out to gather data. The Bayesian model average method was used to identify factors significantly associated with waste generation. Multivariate linear regression analysis was then applied to evaluate th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2019
ISSN: 1932-6157
DOI: 10.1214/18-aoas1223